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alpha-酮戊二酸

CAS號	328-50-7
規格	1kg/袋	純度	工業級99.9%
貨號	HATCH500	貨期	需咨詢
品牌	海曲	庫存	200kg
規格	1kg/袋
純度	工業級99.9%
貨號	HATCH500
貨期	---
品牌	海曲
庫存	200kg
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥350.00

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貨號	品牌	純度	規格	參考價	貨期
HATCH500	海曲	工業級99.9%	1kg/袋	￥350.00	---
11252	---	99%	按需包裝千克/桶	需詢盤	---
10408	---	99%	按需包裝千克/包	需詢盤	---

產品詳情

詳細信息(中文)：
簡介編輯
α-酮戊二酸（英語：α-Ketoglutaric acid）是戊二酸的兩種帶酮基的衍生物中的一種（如果不特別說明，“酮戊二酸”這個術語大多數指的就α型。β-酮戊二酸只是酮基的位置不同而已，并且不太常用）白色細結晶性粉末。熔點113.5℃。易溶于水、醇、極難溶于醚，久貯變淡灰黃色，易潮解。 [1]
這種物質的陰離子，α-酮戊二酸鹽是一種重要的生物化合物。它是谷氨酸脫氨基的酮酸產物，并且是三羧酸循環的中間產物。 [2]
功能編輯
三羧酸循環
α-酮戊二酸是微生物三羧酸循環中重要的代謝中間產物，是連接細胞內碳-氮代謝的關鍵節點，在循環中的位置位于異檸檬酸之后以及琥珀酰輔酶A之前。在這一部位，回補反應可以通過自谷氨酸的轉氨基作用產生α-酮戊二酸而達到補充此中間代謝產物的目的，通過谷氨酸脫氫酶作用于谷氨酸也可以達到這一目的。 [2]
生成氨基酸
谷氨酸在谷氨酰胺合酶的作用下可以生成谷氨酰胺，此酶使用一分子ATP以產生谷氨酰磷酸鹽；這一中間產物被作為親核試劑的氨攻擊，從而形成谷氨酰胺與無機磷酸。 [3]
膳食補充品
α-酮戊二酸作為膳食補充品出售，商品名為AKG或a-KG，賣給健身愛好者或健美運動員，銷售方聲稱這種物質可以提高訓練頂峰時的表現。銷售方聲稱這是基于“研究表明過多的氨可以結合到α-酮戊二酸上被帶走以減少氨中毒帶來的眾多問題”。然而，表現出α-酮戊二酸可以減少氨中毒有效的唯一研究僅僅用于已進行血液透析的患者。 [4]
別名 [5]
2-酮基戊二酸
CAS號
328-50-7
MeSH
alpha-ketoglutaric+acid
化學式
C5H6O5
摩爾質量
146.11 g·mol^-1
熔點
113.5
溶解性（四氫呋喃，乙醇，甲醇）
四氫呋喃：2.33 M，乙醇：1.94 M，甲醇：3.75 M
InChIKey:
KPGXRSRHYNQIFN-UHFFFAOYSA-N

詳細信息(英文)：
Introduction to edit
Alpha ketone glutaric acid (English: alpha Ketoglutaric acid) are two kinds of glutaric acid with ketone group of derivatives of a (if not specified otherwise, the term "ketone glutaric acid" most refers to the type of alpha. Beta - ketone glutaric acid just different from the location of the keto group, and less commonly used) white crystalline powder. The melting temperature of 113.5 ℃. Soluble in water, alcohol, extremely difficult to soluble in ether, long storage become yellow light gray, easy deliquescence. [1]
The substance of the anion, alpha ketone glutaric acid salt is a kind of important biological compounds. It is the keto acid production of glutamate deamination, and the product is in the middle of the tricarboxylic acid cycle. [2]
Function to edit
The Krebs cycle
Alpha ketone glutaric acid is important in the Krebs cycle as A metabolic intermediate, is the key to connect the carbon - nitrogen metabolism in cells nodes, place in the circle in the isocitrate after and before succinyl coa. In this place, covering the reaction can be created by transamination of glutamic acid from alpha ketone glutaric acid, and achieve the goal that complement the intermediate metabolites by glutamate dehydrogenase in glutamic acid can also achieve this goal. [2]
Generate amino acids
Glutamic acid in glutamine synthase can be generated under the action of glutamine, which USES a ATP molecules to produce a glutamine phosphate; This intermediate was used as a nucleophilic reagent ammonia attack, forming a glutamine and inorganic phosphate. [3]
Dietary supplements
Alpha ketone glutaric acid sold as a dietary supplement, called AKG or a - KG goods, sold to bodybuilders or bodybuilder, sellers claim that this kind of material can improve the performance of training the peak. Sellers claim that this is based on "the research shows that excess ammonia can be combined to alpha ketone glutarate was taken on to reduce many of the problems of ammonia poisoning".

產品實物圖

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物理化學性質
英文名	2-oxoglutaric acid
中文名	alpha-酮戊二酸
CAS號	328-50-7	溶解性	---
分子量	146.09800	熔點	113-115 °C
密度	1.54g/cm3	沸點	320.7°C at 760 mmHg