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2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide

CAS號	1403764-72-6
規格	10mg50mg	純度	98%
貨號	HY-16586	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	10mg50mg
純度	98%
貨號	HY-16586
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥1450.00 元/10mg

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貨號	品牌	純度	規格	參考價	貨期
HY-16586	Medchemexpress	98%	10mg50mg	￥1450.00元/10mg	3天

產品詳情

詳細信息(中文)：
PFI-1能阻斷BET BRDs與H3、H4乙酰化組蛋白尾巴的相互作用。

詳細信息(英文)：
產品描述：PFI-1PFI-1 can efficiently block the interaction of BET BRDs with H3 and H4 acetylated histone tails. _x000D_ IC50 Value: 1.89 nM (EC50 for the inhibition of IL6 production from human blood mononuclear cells stimulated by LPS)_x000D_ Target: BET BRDs_x000D_ Inhibition of the BET-histone interaction results in transcriptional downregulation of a number of oncogenes, providing a novel pharmacologic strategy for the treatment of cancer._x000D_ in vitro: Exposure of sensitive cell lines with PFI-1 results in G1 cell-cycle arrest, downregulation of MYC expression, as well as induction of apoptosis and induces differentiation of primary leukemic blasts. Intriguingly, cells exposed to PFI-1 showed significant downregulation of Aurora B kinase, thus attenuating phosphorylation of the Aurora substrate H3S10 [1], The compound showed

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物理化學性質
英文名	2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide
中文名	2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide
CAS號	1403764-72-6	溶解性	---
分子量	347.38900	熔點	---
密度	---	沸點	---