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Vinflunine

CAS號	162652-95-1
規格	5mg10mg	純度	98%
貨號	HY-B0628	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	5mg10mg
純度	98%
貨號	HY-B0628
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥1252.00 元/5mg

立即詢盤

貨號	品牌	純度	規格	參考價	貨期
HY-B0628	Medchemexpress	98%	5mg10mg	￥1252.00元/5mg	3天

產品詳情

詳細信息(中文)：
Vinflunine是新型氟化長春花生物堿，有阻斷有絲分裂和微管蛋白相互作用的活性。

詳細信息(英文)：
產品描述：VinflunineVinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity._x000D_ Target: Microtubule/Tubulin_x000D_ The major effects of Vinflunine on dynamic instability are a slowing of the microtubule growth rate, an increase in growth duration, and a reduction in shortening duration. The effects of Vinflunine on the readmilling rate is examined by following [3H]GTP incorporation into MAP-rich microtubules, and the IC50 is 0.42 μM [1]. Vinflunine induced mitotic accumulation with IC50 with 18.8 nM, which decreases the centromere dynamicity by 44% and increases the time centromeres spent ina paused state by 63% [2]. Treatment of Vinflunine induces a rapid change in endothelial cell shape: cells retracts and assumes a rounded morphology. Mean IC50 values are 9.9 × 10-5 M × 10-5 M for fibronectin and 5.0× 10-5 M × 10-5 M for type IV collagen. A short 4 hours exposure of endothelial cells to Vinflunine at 10-8